External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT04855786
Status
Recruiting
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Conditions

  • Sepsis
  • Septic Shock

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Thoracic duct drainage — PROCEDURE
    drain placement into the thoracic duct

Study Details

To demonstrate that external drainage of thoracic duct lymph during sepsis results in a reduction in circulating pro-inflammatory cytokines. To demonstrate safety and feasibility of early thoracic duct cannulation and external lymph drainage for up to 7 days in adult surgical intensive care patients. To explore other biochemical and physiological endpoints that can be used for the design of future randomized controlled trials and estimate effect size of external drainage.

Key Dates

Start date
Jan 4, 2026
Status verified
Feb 2026
Primary completion
Jul 1, 2027
Completion
Jul 1, 2028

Study Design

Enrollment
10 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Thoracic Duct Drainage
    This is the main study group of patients with thoracic duct drainage

Primary Outcome Measure

Reduction in circulating pro-inflammatory cytokines [ Time Frame: over 7 days of drainage ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Hospital of the University of PennsylvaniaPhiladelphiaPennsylvania19104
Niels D Martin, MD
[email protected]
215-662-7320
Seema Anandalwar, MD
[email protected]
215-662-7320
Niels Martin, MD (PRINCIPAL_INVESTIGATOR)

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By research site
Hospital of the University of Pennsylvania· Philadelphia, PA

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