Tissue Collection for Drug Screening and Bioanalysis

Part of paid clinical trials in New York, New York.

Sponsor
Weill Medical College of Cornell University
Study ID
NCT04852354
Status
Recruiting
Apply to this trial

Conditions

  • Central Nervous System Tumor

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Accepted

Study Details

The purpose of this study is to improve upon the knowledge currently available about central nervous system (CNS) tumors. We will study the different characteristics of these tumors using tissue samples collected during surgery and post-autopsy. The aim is to create tumor cell lines and models to test how they respond to different drugs. This research will help improve treatment options and identify new targets for therapy.

Key Dates

Start date
Jul 22, 2020
Status verified
Dec 2025
Primary completion
Jul 22, 2029
Completion
Jul 22, 2029

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Cohort 1: Tumor patients undergoing neurosurgery
    Samples of tumor tissue, blood, CSF, saliva, skull, and dura will be taken during neurosurgery from tumor patients meeting the inclusion criteria.
  • Arm: Parents of tumor patients
    Saliva samples will be taken from parents of tumor patients meeting the inclusion criteria.
  • Arm: Cohort 2: Non-Tumor patients undergoing neurosurgery
    Blood and CSF samples will be taken from non-tumor patients meeting the inclusion criteria.
  • Arm: Cohort 3: Autopsy tumor tissue donation
    Post-mortem biospecimens such as whole brain, spinal cord, biofluids (e.g., cerebrospinal fluid and blood) and skin biopsy will be collected through autopsy donation from brain tumor patients meeting the inclusion criteria.

Primary Outcome Measure

Evaluating and characterizing the genetic, immunohistochemical, cellular, and molecular profiles of pediatric neoplastic lesions [ Time Frame: Through study completion, average 1-3 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Weill Cornell MedicineNew YorkNew York10021
Jeffrey Greenfield, M.D.
[email protected]
212-746-2363
Pediatric Neurosurgery
[email protected]
212-746-2363
Jeffrey Greenfield, M.D. (PRINCIPAL_INVESTIGATOR)

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Weill Cornell Medicine· New York, NY

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