Cognition and Motor Learning Post-stroke

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of Southern California
Study ID
NCT04829071
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • CVA (Cerebrovascular Accident)
  • Stroke

Eligibility Criteria

Sex
ALL
Age
45 Years - 85 Years
Healthy Volunteers
Not accepted

Interventions

  • Explicit motor learning — BEHAVIORAL
    Participants will be provided with visual feedback of their right and left step lengths on a screen in front of a treadmill.
  • Implicit motor learning — BEHAVIORAL
    Participants will walk on a treadmill that drives their right and left legs to move at two different speeds.

Study Details

This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.

Key Dates

Start date
Jan 16, 2023
Status verified
Oct 2025
Primary completion
Aug 14, 2026
Completion
Dec 14, 2026

Study Design

Enrollment
65 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Evaluating motor learning and brain structures post-stroke
    We will use a single arm design to determine the impact of post-stroke cognitive impairment on two forms of motor learning (implicit and explicit) and evaluate the structural integrity of relevant brain structures in 65 individuals post stroke

Primary Outcome Measure

step length asymmetry - change in performance [ Time Frame: Measured at three timepoints of interest within each testing session: baseline and at the beginning and end of the interventions; participants will complete 2 testing sessions over approximately 1 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Health ProfessionsLos AngelesCalifornia90033
Kristan Leech, PT, DPT, PhD
3124421583

Find similar trials in Los Angeles, CA

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Center for Health Professions· Los Angeles, CA

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