AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry (AVAIL)

Part of paid clinical trials in Orlando, Florida.

Sponsor
AdventHealth Translational Research Institute
Study ID
NCT04807868
Status
Recruiting
Apply to this trial

Conditions

  • Non-Alcoholic Fatty Liver Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Standard of care liver biopsy — PROCEDURE
    Patients undergoing a standard of care liver biopsy for any reason who are willing to participate will be consented for collecting additional biopsy tissue for research purposes. 1-2 additional biopsy tissue cores will be collected for research. Liver tissue will be biobanked for future use.
  • Fibroscan — OTHER
    A FibroScan will be performed to evaluate longitudinal changes in liver fat and fibrosis.
  • Biospecimen Collection — OTHER
    Blood and urine will be collected.

Study Details

The purpose of this study is to create a resource that will advance research that is focused on discovery of novel therapies, risk stratification, and aggressive interventions for those at highest risk for non-alcoholic fatty liver disease (NAFLD). To achieve this, we will generate a biobank of liver tissue collected during standard of care liver biopsies. Paired blood/urine samples, FibroScan and relevant data will also be collected.

Key Dates

Start date
Apr 22, 2021
Status verified
Mar 2025
Primary completion
Dec 31, 2025
Completion
Mar 31, 2026

Study Design

Enrollment
1,250 participants (estimated)

Arms

  • Arm: Biopsy Group
    Adults undergoing a standard of care liver biopsy at AdventHealth Central Florida Division for any reason
  • Arm: Non-Biopsy Group
    Adults without any history of NAFLD

Primary Outcome Measure

Creation of a Biobank of Liver Tissue Paired with a Registry of Histological and Clinical Metadata [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
AdventHealth Translational Research InstituteOrlandoFlorida32804
Recruitment Department
[email protected]
407-303-7100

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