Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant

Conditions

• Post-Lung Transplantation Bronchiectasis

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• POWERBreathe Plus® — DEVICE
  Commercially available pressure-threshold device
• Cardiopulmonary rehabilitation post lung transplant — OTHER
  Pulmonary function, lung diffusing capacity for carbon monoxide, inspiratory muscle strength, and diaphragm dimensions will be assessed in each patient. Each patient will also undergo a cardiopulmonary exercise test (CPET), 6 minute walk test, and an inspiratory muscle endurance test

Study Details

The purpose of this research is to study the effect of training the inspiratory muscles (i.e. the muscle that allow you to breath-in) on exercise capacity, quality of life, and short-term clinical outcomes in patients post lung transplant.

Key Dates

Start date

May 10, 2021

Status verified

Jan 2026

Primary completion

Dec 31, 2026

Completion

Dec 31, 2027

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Arms

• Experimental: 12-weeks pulmonary rehabilitation training plus inspiratory muscle training
  To assess maximum inspiratory pressure, you will be asked to breathe through a device called POWERBreathe Plus®. This device is commercially available and will be provided to you by the study. You will be asked to use this device twice per day, 5 days per week, for 12 weeks. Each session will require you to breathe into the device 30 times. You can use the device at home.
• Placebo Comparator: 12-weeks pulmonary rehabilitation plus placebo (inactive) inspiratory muscle
  To assess maximum inspiratory pressure with placebo, you will be asked to breathe through a device called POWERBreathe Plus®. This device is commercially available and will be provided to you by the study. You will be asked to use this device twice per day, 5 days per week, for 12 weeks. Each session will require you to breathe into the device 30 times. You can use the device at home. The resistance will be set to about 5% throughout the study.

Primary Outcome Measure

Maximal inspiratory mouth pressure (MIP) measured in cmH2O [ Time Frame: 12 weeks ]

Central Contacts

• Bryan Taylor
  [email protected]

Locations (1)

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