Neural Biomarkers of Electroconvulsive Therapy Response

Part of paid clinical trials in Glen Oaks, New York.

Sponsor
Northwell Health
Study ID
NCT04763655
Status
Recruiting
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Conditions

  • Electroconvulsive Therapy Treated Patients

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • clinical and neuropsychological testing — DIAGNOSTIC_TEST
    Patients are monitored with Brief Psychiatric Rating Scale (BPRS) weekly and structural and functional MRI and MATRICS battery before and at the end of the course of the study

Study Details

In the proposed study, the investigators will utilize resting-state functional MRI (fMRI) and structural MRI-based electrical field modeling to study the effect of electroconvulsive therapy on human neural circuitry. Our study will recruit patients who are beginning treatment with bilateral electroconvulsive therapy (N=75). Our design will be longitudinal where patients will be followed up until their 8th week electroconvulsive therapy clinically. The primary measure of interest will be the slope of clinical change estimated with mixed effect modeling (see Approach). Secondary measures will be the cognitive performance change between baseline and the 8th week electroconvulsive therapy time point.

Key Dates

Start date
Apr 1, 2020
Status verified
Sep 2024
Primary completion
Dec 1, 2024
Completion
Jul 1, 2025

Study Design

Enrollment
75 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Other: Treatment as usual

Primary Outcome Measure

Rate of Response to Brief Psychiatry Rating Scale (BPRS) [ Time Frame: Baseline and 8 weeks. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Zucker Hillside HospitalGlen OaksNew York11004
Heela Azizi
[email protected]
718-470-8165

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The Zucker Hillside Hospital· Glen Oaks, NY