Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy

Part of paid clinical trials in Huntington, West Virginia.

Sponsor
Marshall University
Study ID
NCT04755764
Status
Recruiting
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Conditions

  • Cardiac Output, High
  • Cardiac Output, Low
  • Diastolic Hypertension
  • Pregnancy Related
  • Systolic Hypertension

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Labetalol — DRUG
    Beta blocker
  • Atenolol — DRUG
    Beta blocker
  • Nifedipine — DRUG
    Calcium channel blocker

Study Details

The purpose of the research is to characterize the effect of labetalol, atenolol, and nifedipine on maternal hemodynamics early in pregnancy. Patients will be given medication based on their hemodynamics and asked to return for a repeat measurement.

Key Dates

Start date
Mar 3, 2021
Status verified
May 2025
Primary completion
Dec 31, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: Beta blockade
    Beta blocker (labetalol or atenolol) will be given for a cardiac output \>8 l/min.
  • Arm: Nifedipine
    Nifedipine will be given for a mean arterial pressure \>100.

Primary Outcome Measure

Systolic blood pressure [ Time Frame: Initial assessment of hemodynamic parameters will be measured. A change from baseline will be assessed one week later. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Maternal Hypertension Center at Cabell Huntington HospitalHuntingtonWest Virginia25701
Jesse Cottrell, MD
[email protected]
3046911400
Morgan Ruley, MS
[email protected]
3046911458
Jesse Cottrell, MD (PRINCIPAL_INVESTIGATOR)
David Chaffin, MD (SUB_INVESTIGATOR)

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By research site
Maternal Hypertension Center at Cabell Huntington Hospital· Huntington, WV

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