Liver Transplantation for Unresectable Liver Limited Colorectal Metastases

Conditions

• Unresectable Liver-limited Colorectal Metastases

Eligibility Criteria

Sex

ALL

Age

18 Years - 65 Years

Healthy Volunteers

Not accepted

Interventions

• Liver transplant — PROCEDURE
  Eligibility for liver transplantation will be limited to patients with histologically confirmed metastatic colorectal adenocarcinoma who have achieved stability of liver metastasis on chemotherapy for at least 6 months prior to transplantation. All patients who undergo liver transplantation will start immunosuppressive therapy per protocol. Patients who undergo a successful liver transplant will not receive adjuvant therapy.

Study Details

This is a single-arm, single institution pilot registry of liver transplantation in patients with unresectable colorectal liver-only metastases at Weill Cornell Medical College. Patients with liver predominant colorectal liver metastases will be screened based on eligibility criteria in a specified clinical hepatobiliary and colorectal liver metastasis tumor board consisting of the principal and co-investigators, representing medical oncology, transplant surgery, radiology, and pathology. The registry aims to track basic demographic data as well as referral patterns, in addition to specific oncologic data such as tumor burden, extent of disease, extent of disease on explant, recurrence rates, patterns of recurrence and survival rates.

Key Dates

Start date

Sep 30, 2020

Status verified

Dec 2025

Primary completion

Jul 27, 2034

Completion

Jul 27, 2035

Study Design

Enrollment

20 participants (estimated)

Primary Outcome Measure

To develop a registry of liver transplantation in patients with liver limited metastatic colorectal cancer at Weill Cornell Medical College / New York-Presbyterian Hospital (WCMC / NYPH) [ Time Frame: 25 years ]

Central Contacts

• Benjamin M Samstein, MD
  212-746-2127
  [email protected]

Locations (1)

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