The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients

Part of paid clinical trials in Indianapolis, Indiana.

Sponsor
Indiana University
Study ID
NCT04700657
Status
Recruiting
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Conditions

  • Ocular GVHD

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • corneal sensation test — DIAGNOSTIC_TEST
    Thorough ocular surface study including corneal sensation test in the GVHD group, comparing to the normal control group

Study Details

The Investigators hypothesize that the recalcitrant nature of ocular GVHD may be related to corneal nerve damage and corneal hypoesthesia. The investigators aim to study the prevalence of corneal hypoesthesia in GVHD patients and its correlation with ocular surface changes.

Key Dates

Start date
Dec 17, 2020
Status verified
Oct 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
30 participants (estimated)

Arms

  • Arm: 15 patients affected by ocular GVHD
  • Arm: 15 age-matched normal volunteers.

Primary Outcome Measure

Corneal Hypoesthesia [ Time Frame: Baseline clinic visit ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Glick Eye Institute - Indiana UniversityIndianapolisIndiana46202
Linda Morgan
[email protected]
317-274-2745
Michele Spriggs
[email protected]
317-274-2745

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By research site
Glick Eye Institute - Indiana University· Indianapolis, IN