Cardiogenic Shock Working Group Registry

Part of paid clinical trials in Weston, Florida.

Sponsor: Tufts Medical Center
Study ID: NCT04682483
Status: Recruiting

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Conditions

Cardiogenic Shock

Eligibility Criteria

Sex: ALL
Age: 18 Years - N/A
Healthy Volunteers: Not accepted

Interventions

Vasopressor — DRUG
The vasopressors include phenylephrine, norepinephrine, epinephrine, dopamine and vasopressin.
Inotrope — DRUG
Inotropes include dobutamine and milrinone.
Acute Mechanical Circulatory Support Devices — DEVICE
Acute Mechanical Circulatory Support devices include ECMO (VV), ECMO (VA), Impella CP, Impella 2.5, Impella 5.0, Impella 5.5, Impella RP, IABP, Centrimag, Tandem Heart and ProTek Duo.

Study Details

The Cardiogenic Shock Working Group is a multicenter registry where we collect de-identified clinical variables from the medical records and follow-up phone calls of shock patients from multiple institutions and centralize this data to a single registry for analysis of clinical outcomes.

Key Dates

Start date: Dec 4, 2017
Status verified: Jun 2025
Primary completion: Jan 1, 2026
Completion: Jun 1, 2026

Study Design

Enrollment: 5,000 participants (estimated)

Arms

Arm: Cardiogenic Shock Patients
Cardiogenic Shock patients eligible for this study are defined by at least one of the two categories below. 1. Patients have at least 2 of the following concurrently at any point during the index hospitalization: MAP \< 60mmHg or a \>30mmHg drop in MAP from baseline, SBP \< 90mmHg or a \>30mmHg drop in SBP from baseline, Pulse \> 100, Cardiac Index \< 2.2, Cardiac Power Output ≤ 0.6 or PAPI \< 1.0. 2. Patients require the use of at least 1 vasopressor, inotrope or acute mechanical circulatory support device to maintain values above the above targets.

Primary Outcome Measure

Rate of Mortality [ Time Frame: 30 days after discharge ]

Central Contacts

Navin K Kapur, MD
6176368252
[email protected]

Locations (16)

Facility	City	State	ZIP	Site coordinators
Cleveland Clinic Florida	Weston	Florida	33331	Jaime Hernandez-Montfort, MD MPH Jaime Hernandez-Montfort, MD MPH (PRINCIPAL_INVESTIGATOR)
Northwestern Medicine	Chicago	Illinois	60611	Esther Vorovich, MD Esther Vorovich (PRINCIPAL_INVESTIGATOR)
University of Chicago	Chicago	Illinois	60612	Sandeep Nathan, MD Sandeep Nathan, MD (PRINCIPAL_INVESTIGATOR)
Maine Medical Center	Portland	Maine	04102	Andrew Schwartzman, MD Andrew Schwartzman, MD (PRINCIPAL_INVESTIGATOR)
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Arthur R Garan Arthur R Garan, MD (PRINCIPAL_INVESTIGATOR)
Tufts Medical Center	Boston	Massachusetts	02111	Navin K Kapur, MD [email protected] 6176366140 Navin Kapur, MD (PRINCIPAL_INVESTIGATOR)
Hackensack Meridian Health	Hackensack	New Jersey	07601	Haroon Faraz, MD Haroon Faraz, MD (PRINCIPAL_INVESTIGATOR)
Columbia University Irving Medical Center	New York	New York	10032	Justin Fried, MD Justin Fried, MD (PRINCIPAL_INVESTIGATOR)
Providence St. Vincent Heart Clinic	Portland	Oregon	97225	Jacob Abraham, MD Jacob Abraham, MD (PRINCIPAL_INVESTIGATOR)
Allegheny General Hospital	Pittsburgh	Pennsylvania	15212	Manreet Kanwar, MD Manreet Kanwar, MD (PRINCIPAL_INVESTIGATOR)
University Of Pittsburgh Medical Center	Pittsburgh	Pennsylvania	15261	Gavin Hickey, MD Gavin Hickey, MD (PRINCIPAL_INVESTIGATOR)
Baylor Scott & White Advanced Heart Failure Clinic	Dallas	Texas	75201	Detlef Wencker, MD Detlef Wencker, MD (PRINCIPAL_INVESTIGATOR)
University of Texas Medical Branch	Galveston	Texas	77555	Wissam Khalife, MD Wissam Khalife
Houston Methodist Hospital	Houston	Texas	77030	: Ju H Kim, MD Ju H Kim, MD (PRINCIPAL_INVESTIGATOR)
Inova Health System	Falls Church	Virginia	22042	Shashank Sinha, MD, MSc Shashank Sinha, MD, MSc (PRINCIPAL_INVESTIGATOR)
University of Washington Medical Center	Seattle	Washington	98195-9472	Claudius Mahr, DO Claudius Mahr, DO (PRINCIPAL_INVESTIGATOR)

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By research site

Cleveland Clinic Florida· Weston, FL Northwestern Medicine· Chicago, IL University of Chicago· Chicago, IL Maine Medical Center· Portland, ME Beth Israel Deaconess Medical Center· Boston, MA Tufts Medical Center· Boston, MA

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