Discarded Bone Marrow for Hematology Research

Part of paid clinical trials in Memphis, Tennessee.

Sponsor
St. Jude Children's Research Hospital
Study ID
NCT04671212
Status
Recruiting
Apply to this trial

Conditions

  • Hemoglobinopathies

Eligibility Criteria

Sex
ALL
Age
N/A - N/A
Healthy Volunteers
Not accepted

Study Details

The primary objective of this study is to establish a mechanism to obtain discarded bone marrow-containing bone samples from hemoglobinopathy, as well as non-hemoglobinopathy individuals. The processing of samples will help to understand how best to manipulate HSPC's from hemoglobinopathy patients with gene therapy and gene technologies in the laboratory environment. It will also allow us to establish a reservoir of samples that can be studied in the future to assess cellular function and fitness for transplant. Secondary objectives * To develop gene transfer and gene editing strategies as potentially curative therapy for hemoglobinopathies (e.g. sickle cell disease (SCD) and β-thalassemia). * To develop a drug treatment strategy which elevates the expression of fetal hemoglobin to a potentially curative level for hemoglobinopathies. * To examine the biology of bone marrow cells isolated from patients with hemoglobinopathies.

Key Dates

Start date
Jul 26, 2022
Status verified
Apr 2026
Primary completion
Jan 31, 2030
Completion
Jan 31, 2035

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Orthopedic Surgery Patients
    Participants receiving orthopedic surgery for clinical management that involve bone marrow containing bone discard.

Primary Outcome Measure

Collection, processing and storage of discarded bone marrow-containing bone samples from hemoglobinopathy, as well as non-hemoglobinopathy individuals. [ Time Frame: After completion of sample collection, approximately 10 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
St. Jude Children's Research HospitalMemphisTennessee38105
Shannon McKinney-Freeman, Ph.D.
[email protected]
888-226-4343
Shannon McKinney-Freeman, Ph.D. (PRINCIPAL_INVESTIGATOR)

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St. Jude Children's Research Hospital· Memphis, TN

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