4D-MRI for Precision Medicine

Part of paid clinical trials in Charlottesville, Virginia.

Sponsor
University of Virginia
Study ID
NCT04657042
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 82 Years
Healthy Volunteers
Accepted

Interventions

  • Magnetic Resonance Imaging — DIAGNOSTIC_TEST
    Four-dimensional MRI of torso

Study Details

The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!) This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For radiation therapy to be effective, the precise size, shape, and location of the tumor within the body must be known. A particular difficulty for radiation treatment of lung and liver cancer is that the tumor moves during treatment because the patient is breathing. Therefore, tumor motion must also be incorporated into the treatment plan. This study aims to improve radiation treatment planning through better targeting and dose estimation based on 4D-MRI. Before this new imaging method can be used for radiation treatment planning, it must be tested in living, breathing volunteers.

Key Dates

Start date
Nov 5, 2020
Status verified
Apr 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2030

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Healthy
    Healthy volunteers from the local community
  • Arm: Liver cancer
    Patients undergoing radiotherapy for liver cancer
  • Arm: Lung cancer
    Patients undergoing radiotherapy for lung cancer

Primary Outcome Measure

Image quality metrics in healthy volunteers [ Time Frame: single imaging session, lasting up to 2 hours ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of VirginiaCharlottesvilleVirginia22908
Roselove Nunoo-Asare, MA
[email protected]
5402955399

Find similar trials in Charlottesville, VA

By condition
Liver cancerLung cancer
By specialty
OncologyGI oncologyHepatologyLung oncologyLung disease
By research site
University of Virginia· Charlottesville, VA

Related Studies