A Pilot Study Evaluating the Effect of 2D Antiscatter Grids on CBCT Image Quality

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT04565457
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Research CBCT — DEVICE
    Each study participant will receive one additional CBCT scan, with 2D antiscatter grid in place. This is the only intervention in the study, referred as research CBCT scan, and it will be performed on one of the days during the participant's radiation treatment course. This additional research CBCT scan will be used strictly for the objectives of this study. It will not be used as part of the standard clinical care, such as imaging guidance of participant's radiation treatment or diagnostic purposes. To deliver participant's radiation treatment under CBCT guidance, a standard clinical CBCT scan will be acquired, as in standard clinical care protocols.

Study Details

This is Pilot study that investigates the CBCT(Cone beam computed tomography) image quality improvement provided by the 2D antiscatter grid technology. The primary objective is to assess the improvement in tissue visualization in an observer study, which will be conducted in a blinded fashion.

Key Dates

Start date
Apr 21, 2023
Status verified
Apr 2026
Primary completion
May 28, 2025
Completion
May 28, 2025

Study Design

Enrollment
43 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Participants Scanned
    All participants will be scanned with a CBCT system equipped with 2D antiscatter grid technology, referred to as research CBCT. Each participant will also be scanned with a standard clinical CBCT as part of their standard clinical care, which will serve as the baseline, or control.

Primary Outcome Measure

Ratio of Standard CBCT to Research CBCT HU Error in Photon Therapy Participants [ Time Frame: At time of CBCT imaging session (Day 1) ]

Locations (2)

FacilityCityStateZIPSite coordinators
University of Colorado HospitalAuroraColorado80045-
University of Florida Health Proton Therapy InstituteJacksonvilleFlorida32206-

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