The Impact of Glomerular Disorders on Bone Quality and Strength

Part of paid clinical trials in New York, New York.

Sponsor
Columbia University
Study ID
NCT04528446
Status
Recruiting
Apply to this trial

Conditions

  • Bone Diseases, Metabolic
  • Bone Fracture
  • Glomerular Disease

Eligibility Criteria

Sex
ALL
Age
5 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Dual-energy X-ray absorptiometry — RADIATION
    DXA whole body, hip, spine, and radius at baseline, and 12-month visit.
  • High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) — RADIATION
    HR-pQCT of the radius and tibia at baseline, and 12-month visit.
  • Blood draw and Urine collection — OTHER
    The blood draw can be completed +/- 3 weeks from baseline or 12-month visit.
  • Questionnaires — OTHER
    Questionnaires regarding fracture history, physical activity and dietary intake at baseline, and 12-month visit.

Study Details

The primary objectives of this study are to: (1) determine the impact of glomerular disease on bone strength and (2) investigate the pathophysiologic underpinnings of impaired bone strength in glomerular disease.

Key Dates

Start date
Jun 14, 2019
Status verified
Jun 2024
Primary completion
Dec 31, 2024
Completion
Dec 31, 2024

Study Design

Enrollment
270 participants (estimated)

Arms

  • Arm: BoneGN participants
    Participants who have already been recruited into the CureGN study, or meet its criteria.

Primary Outcome Measure

Change in radius bone strength (failure load) [ Time Frame: Baseline and 12 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Columbia University Irving Medical CenterNew YorkNew York10032
Maria A. Aponte
[email protected]
212-342-4678
Thomas L. Nickolas, MD (PRINCIPAL_INVESTIGATOR)
The Children's Hospital of PhiladelphiaPhiladelphiaPennsylvania19104
Erin Doherty
[email protected]
267-600-6233
Michelle R. Denburg, MD (PRINCIPAL_INVESTIGATOR)

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