Mechanisms and Modulation of Pain Modulatory Capacity

Part of paid clinical trials in Gainesville, Florida.

Sponsor
University of Florida
Study ID
NCT04441619
Status
Recruiting
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Conditions

  • Musculoskeletal Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Accepted

Interventions

  • Delayed onset muscle soreness. — BEHAVIORAL
    Participants will perform a fatiguing exercise protocol for the upper extremity (biceps muscles)

Study Details

This project proposes to understand the sources of pain variability, and demonstrate that pain variability represents fluctuation in natural pain management. The project further proposes to determine if endogenous capacity to modulate pain can be trained to maximize their body's ability to manage pain, much as the way in which athletic performance can be trained.

Key Dates

Start date
Nov 30, 2020
Status verified
Jan 2026
Primary completion
Apr 30, 2026
Completion
Apr 30, 2026

Study Design

Enrollment
180 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Active Comparator: Repeated exposure
    Participants will complete four exercise sessions designed to induce delayed onset muscle soreness in the biceps
  • Active Comparator: Single exposure
    Participants will complete one exercise session designed to induce delayed onset muscle soreness
  • No Intervention: Natural history
    Participants will complete all sensory testing and imaging but not perform any exercise sessions.

Primary Outcome Measure

Change in pain intensity [ Time Frame: Baseline up to 10 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Unversity of FloridaGainesvilleFlorida32611-

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Unversity of Florida· Gainesville, FL

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