Assessing Minimal Residual Disease by Next- Generation Sequencing to Minimize Exposure in People With CLL or SLL Who Have Been Treated With Venetoclax

Part of paid clinical trials in Basking Ridge, New Jersey.

Sponsor
Memorial Sloan Kettering Cancer Center
Study ID
NCT04419519
Phase
PHASE2
Status
Active Not Recruiting

Conditions

  • Chronic Lymphocytic Leukemia (CLL)
  • Small Lymphocytic Lymphoma (SLL)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

This study will find out whether people with CLL or SLL who have received treatment with venetoclax, either alone or in combination with another drug, and who are found to be MRD-negative, can stop treatment with venetoclax and remain off-treatment for 12 months or more. The researchers will also see whether study participants remain MRD-negative after they stop treatment with venetoclax.

Key Dates

Start date
May 13, 2020
Status verified
Jan 2026
Primary completion
May 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
81 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Venetoclax monotherapy
  • Experimental: Venetoclax with anti-CD20 monoclonal antibody

Primary Outcome Measure

Proportion of patients able to remain off CLL/SLL directed therapy [ Time Frame: 2 years ]

Locations (9)

FacilityCityStateZIPSite coordinators
Memorial Sloan Kettering Basking Ridge (All protocol activities)Basking RidgeNew Jersey07920-
Memorial Sloan Kettering Monmouth (All protocol activities)MiddletownNew Jersey07748-
Memorial Sloan Kettering Bergen (All protocol activities)MontvaleNew Jersey07645-
Memorial Sloan Kettering Commack (All protocol activities)CommackNew York11725-
Memorial Sloan Kettering Westchester (All protocol activities)HarrisonNew York10604-
Columbia UniversityNew YorkNew York10032-
Memorial Sloan Kettering Cancer Center (All Protocol Activities)New YorkNew York10065-
Memorial Sloan Kettering Nassau (All protocol activities)UniondaleNew York11553-
University of WashingtonSeattleWashington98109-

Find similar trials in Basking Ridge, NJ

By research site
Memorial Sloan Kettering Basking Ridge (All protocol activities)· Basking Ridge, NJMemorial Sloan Kettering Monmouth (All protocol activities)· Middletown, NJMemorial Sloan Kettering Bergen (All protocol activities)· Montvale, NJMemorial Sloan Kettering Commack (All protocol activities)· Commack, NYMemorial Sloan Kettering Westchester (All protocol activities)· Harrison, NYColumbia University· New York, NY

Related Studies