Macromolecular Imaging of White and Gray Matter Pathology in Multiple Sclerosis

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT04415372
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 60 Years
Healthy Volunteers
Accepted

Interventions

  • MRI — DIAGNOSTIC_TEST
    The MRI protocol will include conventional testing for MS lesion detection and functional MR imaging to localize associated neurocognitive domains in each subject.
  • Neuropsychological Testing — DIAGNOSTIC_TEST
    A comprehensive battery of neuropsychological tests will be administered to assess memory, new learning, spatial processing and higher executive function.

Study Details

The overall purpose of this research is to determine whether new macromolecular measures optimized for whole brain (gray matter and white matter) magnetic resonance imaging (MRI), predict neuro-cognitive impairment in multiple sclerosis (MS) patients.

Key Dates

Start date
Nov 19, 2021
Status verified
Apr 2026
Primary completion
Apr 30, 2027
Completion
Apr 30, 2027

Study Design

Enrollment
75 participants (estimated)

Arms

  • Arm: Cognitive Impairment
    Adults diagnosed with MS that have evidence of cognitive decline.
  • Arm: No Cognitive Impairment
    Adults diagnosed with MS that have no evidence of cognitive decline.
  • Arm: Healthy Controls
    Healthy adult volunteers will form a control group matched for age, gender, education, handedness

Primary Outcome Measure

Measurement of macromolecular proton content (MPC) by Magnetic resonance imaging [ Time Frame: 24 hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Wisconsin, MadisonMadisonWisconsin53705-

Find similar trials in Madison, WI

By condition
Multiple sclerosis
By specialty
NeurologyBrain disordersAutoimmune disease
By research site
University of Wisconsin, Madison· Madison, WI

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