Effects of Combination Exercise on Fatigability in Veterans With Chronic Kidney Disease

Conditions

• Chronic Kidney Disease Predialysis

Eligibility Criteria

Sex

ALL

Age

50 Years - 85 Years

Healthy Volunteers

Accepted

Interventions

• Combination Exercise — BEHAVIORAL
  Flywheel Resistance Plus Aerobic Exercise

Study Details

The VA health care system uses a health promotion-focused model which aims to provide longitudinal care through a patient-aligned care team for Veterans with chronic kidney disease. Since the largest subpopulation of Veterans with chronic kidney disease is comprised of those not requiring dialysis, neuromuscular screening assessments may provide valuable information regarding an individual overall health status and potential for future complications. Furthermore, identifying at risk individuals early in the disease process will allow for the prescription of timely interventions. Exercise strategies such as combination exercise, which uses flywheel resistance plus aerobic exercise, may provide a valuable treatment option for combating neuromuscular dysfunction and functional decline in patients with chronic kidney disease.

Key Dates

Start date

Jun 1, 2022

Status verified

Mar 2026

Primary completion

Apr 1, 2027

Completion

Apr 1, 2027

Study Design

Enrollment

30 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Combination Exercise
  Flywheel resistance exercise plus aerobic exercise
• No Intervention: Standard-of-care
  Participants will maintain standard-of-care and current activity levels during the course of the study.

Primary Outcome Measure

change in knee extensor fatigability [ Time Frame: week 6 and 12 ]

Central Contacts

• Jared M Gollie, PhD
  (202) 745-8000
  [email protected]

Locations (1)

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