Identification of Critical Thermal Environments for Aged Adults

Part of paid clinical trials in University Park, Pennsylvania.

Sponsor
Penn State University
Study ID
NCT04284397
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Low dose ASA — DRUG
    A sub-group of older adults will be re-tested after 7 days of treatment with low-dose aspirin.
  • Control — OTHER
    All participants will be tested with no treatment.

Study Details

This study evaluates critical environmental limits (temperature and humidity) above which older adults are unable to effectively thermoregulate. Participants will exercise in a series of different environmental conditions to identify combinations of temperature and humidity above which age-related physiological changes cause uncompensable heat stress, resulting in increased risk of heat illness.

Key Dates

Start date
Dec 30, 2020
Status verified
Jan 2026
Primary completion
Feb 27, 2027
Completion
Feb 27, 2027

Study Design

Enrollment
190 participants (estimated)
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Critical Environmental Limits
    Subjects will perform exercise at \~200-300W with ambient temperature or humidity increasing every 5 min throughout the trial until core temperature begins to rise.
  • Experimental: Aspirin Supplementation
    After a minimum of 7 days of daily, low-dose aspirin ingestion, older subjects will repeat critical environmental limits trials. As before, subjects will perform exercise at \~200-300W with ambient temperature or humidity increasing every 5 min throughout the trial until core temperature begins to rise.

Primary Outcome Measure

Temperature and humidity limits for maintaining stable core temperature [ Time Frame: Through study completion, an average of 1 year. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Noll LaboratoryUniversity ParkPennsylvania16802
W. Larry Kenney, Ph.D.
[email protected]
814-863-1672
S. Tony Wolf, Ph.D.
[email protected]
814-863-8557

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By research site
Noll Laboratory· University Park, PA

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