Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction - DOSE Finding Study

Part of paid clinical trials in Beverly Hills, California.

Sponsor
Amgen
Study ID
NCT04270760
Phase
PHASE2
Status
Completed

Conditions

  • Cardiovascular Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • Olpasiran — DRUG
    Dose 1 Dose 2 Dose 3 Dose 4
  • Placebo — DRUG
    Dose 5

Study Details

Evaluate the effect of olpasiran administered subcutaneously (SC) compared with placebo, on percent change from baseline in lipoprotein(a) (Lp\[a\]).

Key Dates

Start date
Jul 28, 2020
Status verified
Mar 2026
Primary completion
Dec 27, 2021
Completion
Nov 8, 2022

Study Design

Enrollment
281 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Arm 1 Olpasiran Dose 1
  • Active Comparator: Arm 2 Olpasiran Dose 2
  • Active Comparator: Arm 3 Olpasiran Dose 3
  • Active Comparator: Arm 4 Olpasiran Dose 4
  • Placebo Comparator: Arm 5 Placebo Dose 5

Primary Outcome Measure

Percentage Change From Baseline in Lipoprotein(a) (Lp[a]) at Week 36 [ Time Frame: Baseline and Week 36 ]

Locations (12)

FacilityCityStateZIPSite coordinators
Westside Medical Associates of Los AngelesBeverly HillsCalifornia90211-
Excel Medical Clinical TrialsBoca RatonFlorida33434-
Piedmont HealthcareAtlantaGeorgia30309-
University of Kansas Medical CenterKansas CityKansas66160-
Johns HopkinsBaltimoreMaryland21287-
Columbia University Medical CenterNew YorkNew York10032-
Mount Sinai HospitalNew YorkNew York10029-
New York UniversityNew YorkNew York10016-
Crossroads Clinical Research IncMooresvilleNorth Carolina28117-
Cleveland ClinicClevelandOhio44195-
Baylor College of MedicineHoustonTexas77030-
Protenium Clinical ResearchHurstTexas76054-

Find similar trials in Beverly Hills, CA

By research site
Westside Medical Associates of Los Angeles· Beverly Hills, CAExcel Medical Clinical Trials· Boca Raton, FLPiedmont Healthcare· Atlanta, GAUniversity of Kansas Medical Center· Kansas City, KSJohns Hopkins· Baltimore, MDColumbia University Medical Center· New York, NY

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