OCT in Fuchs' Dystrophy

Conditions

• Fuchs Dystrophy
• Pseudophakic Bullous Keratopathy

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Study Details

This is an observational study using optical coherence tomography (OCT) technology to quantify corneal edema in Fuchs' endothelial dystrophy and predict refractive shift from resolving corneal edema after surgical treatments.

Key Dates

Start date

Jun 26, 2020

Status verified

Sep 2025

Primary completion

Jun 30, 2027

Completion

Jun 30, 2028

Study Design

Enrollment

60 participants (estimated)

Arms

• Arm: Group A: No Surgery Group
  This group consists of adults ages 18 or older who have been diagnosed with Fuchs' dystrophy or pseudophakic bullous keratopathy but do not require surgery per standard-of-care guidelines.
• Arm: Group B: Surgery Group
  This group consists of adults ages 18 or older who have been diagnosed with Fuchs' dystrophy or pseudophakic bullous keratopathy, who require Descemet's Stripping Endothelial Keratoplasty (DSAEK), Descemet's Membrane Endothelial Keratoplasty (DMEK), or Descemet's Stripping Only (DSO) surgery. All treatment decisions will be made by the attending physician based on standard-of-care guidelines. (The study does not designate a treatment modality or pay for the treatment.)

Primary Outcome Measure

Corneal Epithelial Edema/Haze [ Time Frame: up to 2 years ]

Central Contacts

• Humberto Martinez, COT
  503-494-7712
  [email protected]
• Denzil Romfh, OD
  503-494-4351
  [email protected]

Locations (1)

Find similar trials in Portland, OR

Related Studies

• Descemet Endothelial Thickness Comparison Trial II
  PHASE3 · Recruiting · Stanford University · Palo Alto, California