Ketamine for Post-operative Analgesia in Hemorrhoidectomy

Conditions

• Hemorrhoids

Eligibility Criteria

Sex

ALL

Age

18 Years - 100 Years

Healthy Volunteers

Not accepted

Interventions

• Ketamine — DRUG
  Standard general anesthesia PLUS ketamine will be given for post-operative analgesia

Study Details

This is a prospective, randomized study of ketamine versus no ketamine in approximately 100 patients undergoing hemorrhoidectomy for Grade III or IV hemorrhoids. The participants will be blinded to which treatment arm they are assigned, because participants will be under anesthesia when the ketamine is administered. The investigators will know whether the participant receives ketamine or not.

Key Dates

Start date

Jun 15, 2020

Status verified

Mar 2026

Primary completion

Jan 31, 2027

Completion

Jul 31, 2027

Study Design

Enrollment

100 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: Intraoperative ketamine infusion
  Subjects in this group will receive standard anesthesia during surgery and a dose of ketamine at 0.3 mg/kg IV bolus prior to surgical incision. If the procedure lasts more than 1 hour, an additional bolus dose will be given.
• No Intervention: Control group
  This group will only receive the standard anesthesia during surgery with no ketamine.

Primary Outcome Measure

Change in post-operative narcotic usage [ Time Frame: two weeks post-operation ]

Central Contacts

• Steven N Carter, MD
  405-271-8001
  [email protected]

Locations (1)

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