The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

Part of paid clinical trials in Davis, California.

Sponsor
University of California, Davis
Study ID
NCT04248127
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
FEMALE
Age
45 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Honey sweetened yogurt — OTHER
    2 tbsp. of daily honey intake in 1.2 cups of yogurt per day, split into two equal portions
  • Sugar sweetened yogurt — OTHER
    sugar added, in an isocaloric fashion to the honey, to 1.2 cups of yogurt per day, split into two equal portions

Study Details

A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and associative changes with microbial derived metabolites (SCFAs, BAs, ellagitannins), metabolism and the fecal microbiome. The above suite of selected markers will capture diet-induced systemic changes in inflammation and oxidative stress, while assessing associated microbial changes.

Key Dates

Start date
Nov 1, 2021
Status verified
Feb 2026
Primary completion
Jul 25, 2026
Completion
Jul 31, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION

Arms

  • Experimental: Honey sweetened yogurt
    1 tbsp. of honey in 0.6 cup (150g) of plain yogurt. The participants will be asked to consume 2 morning servings of the yogurt for a total of 2 tbsp. of the assigned honey per day.
  • Placebo Comparator: Sugar sweetened yogurt
    Sugar will be added to 0.6 cup (150g) of plain yogurt in an isocaloric amount compared to the honey. The participants will be asked to consume 2 morning servings of the yogurt per day.

Primary Outcome Measure

Concentration of CD4+ T Helper (TH)17 cytokines [ Time Frame: 4 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of California, Davis; Department of NutritionDavisCalifornia95616
Roberta Holt, PhD
[email protected]
530-752-4950

Find similar trials in Davis, CA

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
University of California, Davis; Department of Nutrition· Davis, CA

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