Opioids and Social Support Enhanced Extinction Effects

Part of paid clinical trials in Los Angeles, California.

Sponsor
University of California, Los Angeles
Study ID
NCT04166071
Phase
EARLY_PHASE1
Status
Enrolling By Invitation

Conditions

  • Fear

Eligibility Criteria

Sex
ALL
Age
18 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Naltrexone — DRUG
    Half of the participants will be randomly assigned to take one dose of naltrexone (50mg, capsule form) during the experimental session
  • Placebo — DRUG
    Half of the participants will be randomly assigned to take a placebo capsule during the experimental session

Study Details

University of California, Los Angeles researchers will recruit healthy participants (age 18-35) to participate in a study examining whether the administration of naltrexone, an opioid antagonist, eliminates the ability of social support figure reminders to enhance fear extinction--a process during which a threatening cue is learned to not predict a negative or threatening outcome (i.e., electric shock) by being repeatedly presented in the absence of that outcome. After undergoing an email screening, a telephone screening, an in lab screening, and a health screening, 60 participants will be enrolled in the study. During the experiment, 30 participants will be administered naltrexone and 30 participants will be administered placebo (both participants and experimenters will be blind to condition) before undergoing a fear extinction procedure in which threatening cues--cues that predict electric shock--will be paired with either an image of a social support figure (provided by participants) or a second threatening cue. These pairings will be presented repeatedly in the absence of shock in order for fear extinction to occur. Participants will return for a follow-up test to determine if fear extinction was successful.

Key Dates

Start date
Dec 13, 2021
Status verified
Oct 2025
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Naltrexone
  • Placebo Comparator: Placebo

Primary Outcome Measure

Fear Response directly post-extinction [ Time Frame: Directly following a fear extinction procedure (during the experiment session). ]

Locations (2)

FacilityCityStateZIPSite coordinators
UCLALos AngelesCalifornia90095-
UCLA Department of Psychology, 5514 Pritzker HallLos AngelesCalifornia90095-1563-

Find similar trials in Los Angeles, CA

By research site
UCLA· Los Angeles, CAUCLA Department of Psychology, 5514 Pritzker Hall· Los Angeles, CA

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