Motor rECovery witH eArly imagiNg In STroke

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT04165616
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Not accepted

Study Details

This study will contribute to the field of stroke rehabilitation research by expanding the investigator's understanding of the neural mechanisms responsible for the development and expression of abnormal flexion synergy, a primary movement impairment due to stroke. The study will longitudinally evaluate motor tract morphology and motor impairment/function in an attempt to develop early neuroimaging-based predictors of the development of flexion synergy and its impact on reaching and hand recovery (6 month). The study will utilize quantitative motor testing (kinematics and kinetics) to measure motor impairment and reaching and hand function. Both neuroimaging and quantitative motor testing will be conducted within 96 hours-, 2 weeks-, 3 months-, and 6 months-post stroke. The knowledge gained by this study will provide crucial structural and functional neuroimaging evidence that demonstrates the timeline of progressive ipsi- and contralesional motor pathway (including bulbospinal pathways) changes and the associated development of flexion synergy that grossly impacts reaching and hand function in individuals with moderate to severe stroke.

Key Dates

Start date
Jun 21, 2022
Status verified
Aug 2025
Primary completion
Apr 30, 2026
Completion
Apr 30, 2026

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Individuals with stroke

Primary Outcome Measure

Change in fractional anisotropy [ Time Frame: Change in fractional anisotropy will be modeled over 4 time points (48-96 hours-, 2 weeks-, 3 months-, and 6 months post-stroke). ]

Central Contacts

Locations (3)

FacilityCityStateZIPSite coordinators
Department of Physical Therapy and Human Movement SciencesChicagoIllinois60611
Michael D Ellis, PT, DPT
[email protected]
3125034435
Carolina Carmona, PT, DPT, NCS
[email protected]
3125034633
Michael D Ellis, PT, DPT (SUB_INVESTIGATOR)
Northwestern Memorial HospitalChicagoIllinois60611
Rachel A Vincent, CBIS
[email protected]
312-503-3243
Heidi R Roth, PT, DHS, NCS
[email protected]
312-503-6018
Sebastian Urday, MD (SUB_INVESTIGATOR)
Shirley Ryan AbilityLabChicagoIllinois60611
Val Islas-Montantes
[email protected]
312-238-1522
Heidi R Roth, PT, DHS, NCS
[email protected]
312-503-6018
Richard L Harvey, MD (SUB_INVESTIGATOR)

Find similar trials in Chicago, IL

By condition
Stroke
By specialty
NeurologyBrain disorders
By research site
Department of Physical Therapy and Human Movement Sciences· Chicago, ILNorthwestern Memorial Hospital· Chicago, ILShirley Ryan AbilityLab· Chicago, IL

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