RH Genotype Matched RBC Transfusions

Conditions

• Sickle Cells Disease

Eligibility Criteria

Sex

ALL

Age

6 Months - N/A

Healthy Volunteers

Not accepted

Interventions

• Red cell units that are genotype matched at the RHD and RHCE loci — BIOLOGICAL
  Patients will be provided with red cell units that are C, E, and K antigen matched (standard of care for patients with SCD) and genotype matched at the RHD and RHCE loci.

Study Details

To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

Key Dates

Start date

Jan 30, 2020

Status verified

Apr 2026

Primary completion

Apr 30, 2029

Completion

Oct 31, 2029

Study Design

Enrollment

35 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Arms

• Experimental: RH genotype matched red cell transfusions
  Subjects will receive RH genotyped matched red cell units for transfusion in addition to standard serologic C, E, and K antigen matching and being hemoglobin S negative, which is our institutional standard of care for patients with Sickle Cell Disease.

Primary Outcome Measure

Determine the treatment efficacy by monitoring the rate of Rh alloimmunization [ Time Frame: 3.5 years ]

Central Contacts

• Stella Chou, MD
  215-590-0947
  [email protected]

Locations (1)

Find similar trials in Philadelphia, PA