Effect of tDCS Timing on Safety Memory in PTSD

Part of paid clinical trials in Providence, Rhode Island.

Sponsor
Butler Hospital
Study ID
NCT04152772
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • transcranial direct current stimulation — DEVICE
    Active tDCS will consist of 15 minutes of 2 mA intensity once, either applied during or after extinction learning.

Study Details

The primary purpose of this study is to investigate the effects of tDCS timing on extinction memory in PTSD. A total of 90 participants will be randomized equally across one of three groups: 1. One group receiving active stimulation during extinction followed by sham stimulation during consolidation 2. One group receiving sham stimulation during extinction followed by active stimulation during consolidation 3. One group receiving sham stimulation both during extinction and consolidation This study also includes an online sub-study (Aim 2) focused on contextual processing along the PTSD spectrum. The online study tests if there is an association between threat and non-threat learning in contextual and non-contextual situations. A maximum of 500 participants will be recruited using an online, panel-based platform.

Key Dates

Start date
Nov 22, 2019
Status verified
Oct 2025
Primary completion
Jan 31, 2024
Completion
Jan 31, 2024

Study Design

Enrollment
62 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Active tDCS during extinction learning followed by sham tDCS during consolidation
    Active tDCS will be applied during the extinction learning phase followed by sham tDCS during the consolidation phase.
  • Active Comparator: Sham tDCS during extinction learning followed by active tDCS during consolidation
    Sham tDCS will be applied during the extinction learning phase followed by active tDCS during the consolidation phase.
  • Sham Comparator: Sham tDCS during extinction learning followed by sham tDCS during consolidation
    Sham tDCS will be applied during the extinction learning phase followed by sham tDCS during the consolidation phase.

Primary Outcome Measure

Skin Conductance Responses [ Time Frame: Study visit day 4: during administration of fear extinction memory. ]

Locations (1)

FacilityCityStateZIPSite coordinators
Butler HospitalProvidenceRhode Island02906-

Find similar trials in Providence, RI

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
Butler Hospital· Providence, RI

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