Combination Camrelizumab (SHR-1210) and Apatinib for Downstaging/Bridging of HCC Before Liver Transplant
- Sponsor
- Zhejiang University
- Study ID
- NCT04035876
- Phase
- PHASE1/PHASE2
- Status
- Unknown
Conditions
- Hepatocellular Carcinoma
- Liver Transplant
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 75 Years
- Healthy Volunteers
- Not accepted
Interventions
- Camrelizumab plus apatinib — DRUGCamrelizumab 200mg q2w iv and apatinib 250mg qd po.
Study Details
To assess the primary effects and safety of camrelizumab (SHR-1210) plus apatinib for downstaging/bridging of HCC before liver transplantation.
Key Dates
- Start date
- Jul 16, 2019
- Status verified
- Jul 2019
- Primary completion
- Dec 31, 2021
- Completion
- Dec 31, 2021
Study Design
- Enrollment
- 120 participants (estimated)
- Allocation
- NA
- Intervention model
- SINGLE_GROUP
- Primary purpose
- TREATMENT
Arms
- Experimental: Camrelizumab plus apatinib
Primary Outcome Measure
Objective remission rate [ Time Frame: From enrollment to disease progression, up to 6 months ]
Central Contacts
- Jianguo Wang, PhD(+86)15967123327
Related Studies
- Proteogenomic Monitoring and Assessment of Liver Transplant RecipientsRecruiting · Northwestern University · Chicago, Illinois
- Dose-defining Study of Tirapazamine Combined With Embolization in Liver CancerPHASE1/PHASE2 · Recruiting · Teclison Ltd. · Palo Alto, California
- Combination of TATE and PD-1 Inhibitor in Liver CancerPHASE2 · Recruiting · Teclison Ltd. · Orange, California
- Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal MalignanciesPHASE1/PHASE2 · Recruiting · Anwaar Saeed · Westwood, Kansas