A Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma

Part of paid clinical trials in Gilbert, Arizona.

Sponsor
AVEO Pharmaceuticals, Inc.
Study ID
NCT03970616
Phase
PHASE1/PHASE2
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Tivozanib — DRUG
    Dose level 1: 1.0mg for 21 days followed by 7 days rest; Dose level -1: 1.0mg every other day
  • Durvalumab — DRUG
    1500mg every 28 days

Study Details

This study will evaluate the safety, tolerability, DLTs, MTD, and preliminary anti tumor activity of tivozanib in combination with durvalumab in subjects with advanced HCC.

Key Dates

Start date
Sep 30, 2019
Status verified
Jul 2023
Primary completion
Apr 4, 2023
Completion
Apr 4, 2023

Study Design

Enrollment
27 participants (actual)
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT

Arms

  • Experimental: Tivozanib in Combination with Durvalumab
    Tivozanib in Combination with Durvalumab

Primary Outcome Measure

Incidence of Treatment Emergent Adverse Events (TEAEs) [ Time Frame: Approximately 24 months; Through study completion ]

Locations (10)

FacilityCityStateZIPSite coordinators
Banner MD Anderson Cancer CenterGilbertArizona85234-
City of HopeDuarteCalifornia91010-
University of California - IrvineOrangeCalifornia92868-
Northwestern University Feinberg School of MedicineChicagoIllinois60611-
Dana Farber Cancer InstituteBostonMassachusetts02215-
Roswell Park Cancer InstituteBuffaloNew York14263-
Montefiore Medical CenterThe BronxNew York10467-
UT Southwestern Medical CenterDallasTexas75390-
The University of Texas Health Science Center at Houston (UTHealth)HoustonTexas77030-
The University of Texas Health Science Center at Tyler (UTHealth)TylerTexas75708-

Find similar trials in Gilbert, AZ

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Liver cancer
By specialty
OncologyGI oncologyHepatology
By research site
Banner MD Anderson Cancer Center· Gilbert, AZCity of Hope· Duarte, CAUniversity of California - Irvine· Orange, CANorthwestern University Feinberg School of Medicine· Chicago, ILDana Farber Cancer Institute· Boston, MARoswell Park Cancer Institute· Buffalo, NY

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