Neural Correlates of Sensory Phenomena in Tourette Syndrome

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT03914664
Status
Enrolling By Invitation

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Electroencephalogram (EEG) testing procedure — DIAGNOSTIC_TEST
    EEG testing procedure, comprised of somatosensory and auditory event-related potential paradigms, as well as resting state EEG
  • Autonomic function testing procedure — DIAGNOSTIC_TEST
    Autonomic function testing procedure, comprised of electrodes to determine heart rate variability and electrodermal activity (EDA)

Study Details

The most pervasive sensory manifestation of TS is sensory over-responsivity (SOR). SOR is defined as excessive behavioral response to commonplace environmental stimuli. SOR is an integral but poorly understood facet of the TS phenotype, one intertwined with core elements of the disorder and worse QOL. This proposal seeks to clarify the mechanistic bases of SOR in TS. Adults with with TS will be recruited 1) to complete a standardized clinical symptom assessment battery and 2) to undergo electroencephalogram (EEG), autonomic, and audio-visual monitoring during tactile and auditory stimuli paradigms, as well as at rest.

Key Dates

Start date
Jul 20, 2021
Status verified
Jan 2026
Primary completion
Feb 28, 2027
Completion
Feb 28, 2027

Study Design

Enrollment
50 participants (estimated)

Arms

  • Arm: Tourette Syndrome
    Adults (\>18 years of age) with diagnosis of Tourette syndrome
  • Arm: Healthy Control
    Adults who are generally healthy with no known neurologic or psychiatric diagnoses

Primary Outcome Measure

Network oscillations in response to sensory stimuli [ Time Frame: Baseline ]

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt University Medical CenterNashvilleTennessee37232-5400-

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By research site
Vanderbilt University Medical Center· Nashville, TN

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