Bupivacaine/Epinephrine +Dexamethasone vs. Liposomal Bupivacaine

Conditions

• Robotic Lung Surgery

Eligibility Criteria

Sex

ALL

Age

18 Years - 90 Years

Healthy Volunteers

Not accepted

Interventions

• Intercostal nerve block and wound infiltration with liposomal bupivacaine — DRUG
  Intercostal nerve block and wound infiltration with liposomal bupivacaine during robotic lung resection surgery. 266mg of liposomal bupivacaine with 24 ml of 0.5% bupivacaine will be used.
• Intercostal nerve block and wound infiltration with bupivacaine/epinephrine + dexamethasone — DRUG
  Intercostal nerve block and wound infiltration with liposomal bupivacaine during robotic lung resection surgery. 42 ml of 0.5% Bupivacaine/epinephrine with 8mg dexamethasone will be used.

Study Details

This study will assess analgesia after robotic lung surgery. Subjects will be randomized to receive wound infiltration and intercostal nerve block with either liposomal bupivacaine or bupivacaine/epinephrine + dexamethasone. Liposomal bupivacaine is a newer local anesthetic product and has not been compared to a combination of bupivacaine/epinephrine + dexamethasone in the context of pain control after robotic lung surgery.

Key Dates

Start date

Apr 10, 2019

Status verified

Nov 2021

Primary completion

Apr 10, 2022

Completion

Jun 10, 2022

Study Design

Enrollment

34 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: Bupivacaine/epinephrine + dexamethasone
• Active Comparator: Liposomal bupivacaine

Primary Outcome Measure

Visual Analogue Scale pain scores [ Time Frame: 24 hours post-surgery ]

Central Contacts

• Noud van Helmond, MD
  856-968-7336
  [email protected]

Locations (1)

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