Reducing African Americans' Alzheimer's Disease Risk Through Exercise (RAATE)"

Conditions

• Dementia, Alzheimer Type

Eligibility Criteria

Sex

ALL

Age

60 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Physical activity — BEHAVIORAL
  Promotion of physical activity to the current federal physical activity guidelines.
• Successful Aging — BEHAVIORAL
  Seminars of health topics related to aging in African Americans with light stretching and low intensity activites

Study Details

The RAATE proposal is designed to determine the effects of physical activity on risk factors for Alzheimer's Disease in older African American adults. The study will compare a physical activity program to an active control group. There are three main objectives of the protocol: 1) to determine if a physical activity intervention tailored to older African American adults is effective in modifying cognitive function associated with Alzheimer's Disease, 2) to determine if a physical activity intervention tailored to older African American adults is effective in modifying brain function and structure associated with Alzheimer's Disease, and 3) to determine if a physical activity promotion intervention tailored to African American adults is effective at enhancing physiological parameters. The primary endpoints for the study are episodic memory and executive functioning. The secondary outcomes include anthropometry, blood pressure, brain activation, cerebral blood flow, volume of whole brain and white matter hyperintensities, cardiorespiratory fitness, objectively measured physical activity, circulating hormones, and telomere length.

Key Dates

Start date

Aug 9, 2019

Status verified

Nov 2024

Primary completion

Nov 30, 2025

Completion

Nov 30, 2026

Study Design

Enrollment

125 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Arms

• Experimental: Physical activity intervention
  The intervention group will target 150 minutes of moderate to vigorous aerobic physical activity and two days of strength training, consistent with the current physical activity recommendations. Participants will engage in 2 days per week of supervised activity at community facilities. These participants will be requested to engage in an additional 30 minutes of moderate to vigorous aerobic physical activity two days per week at home.
• Active Comparator: Active control
  The active control group will be based on a low-intensity activity program and a healthy aging educational component. The physical activities will include stretching, balance training, flexibility, relaxation, and practicing activities of daily living. The successful aging education component will cover topics including avoiding scams, fall prevention, living wills, and dementia awareness.

Primary Outcome Measure

Change in episodic memory [ Time Frame: Baseline, 24 weeks, 52 weeks ]

Central Contacts

• Melissa Harris, PhD
  225763091
  [email protected]

Locations (1)

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