Neural Mechanisms of Mindfulness-based Cognitive Therapy (MBCT) for Posttraumatic Stress Disorder (PTSD)

Part of paid clinical trials in Ann Arbor, Michigan.

Sponsor
Ohio State University
Study ID
NCT03874793
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 72 Years
Healthy Volunteers
Not accepted

Interventions

  • Mindfulness-Based Cognitive Therapy — BEHAVIORAL
    Participants will attend 8 weekly group therapy sessions. Prior to and after therapy participants will have assessments related to their PTSD, fill out surveys, and have an fMRI.
  • Muscle Relaxation Therapy — BEHAVIORAL
    Participants will attend 8 weekly group therapy sessions. Prior to and after therapy participants will have assessments related to their PTSD, fill out surveys, and have an fMRI.

Study Details

This study will examine the effects of psychotherapy as treatment for PTSD, and specifically how brain activity and brain connectivity is affected by Mindfulness Based Cognitive Therapy (MBCT) and an active mind-body comparison comparison therapy.

Key Dates

Start date
Jul 29, 2019
Status verified
Feb 2026
Primary completion
Dec 1, 2023
Completion
Mar 1, 2024

Study Design

Enrollment
61 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Mindfulness-Based Cognitive Therapy
    Participants will have 8 weeks of group therapy and will be asked to do MBCT exercises for approximately 20-30 minutes on 5 or more days/week.
  • Active Comparator: Muscle Relaxation Therapy (MRG)
    Participants will have 8 weeks of group therapy participants and will be asked to do MRG exercises for approximately 20-30 minutes on 5 or more days/week.

Primary Outcome Measure

Change (From Intake to Post-therapy) in Resting-state Functional Connectivity Between Posterior Cingulate Cortex (PCC) and Dorsolateral Prefrontal Cortex (dlPFC) [ Time Frame: Intake (pre-therapy) and post therapy (approximately 9 - 10 weeks) ]

Locations (2)

FacilityCityStateZIPSite coordinators
University of MichiganAnn ArborMichigan48109-
Ohio State UniversityColumbusOhio43210-

Find similar trials in Ann Arbor, MI

By condition
PTSD (post-traumatic stress disorder)
By specialty
PsychiatryMental healthBehavioral health
By research site
University of Michigan· Ann Arbor, MIOhio State University· Columbus, OH

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