Exosomes in Rectal Cancer

Part of paid clinical trials in Kansas City, Kansas.

Sponsor
University of Kansas Medical Center
Study ID
NCT03874559
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Blood Draw — DIAGNOSTIC_TEST
    Serum samples will be obtained from each patient enrolled

Study Details

The primary aims of this study is to characterize exosomal biomarker levels in patients with locally advanced rectal cancer undergoing neoadjuvant chemoradiation therapy. Compare rates of exosomal expression before during and after chemoradiation therapy with pathologic response rates at the time of APR or LAR. The researchers will also examine the functionality of these exosomes in malignant colonic organoids and mouse models of colorectal cancer.

Key Dates

Start date
Feb 13, 2018
Status verified
Apr 2026
Primary completion
Feb 1, 2027
Completion
Feb 1, 2028

Study Design

Enrollment
30 participants (estimated)

Arms

  • Arm: Arm A
    All patients enrolled will be placed in Arm A. Serum blood draw samples will be collected as well as additional data from medical records will be collected. This data includes demographic data, clinical information from notes, radiology images and reports, diagnostic test results, and procedure and pathology reports.

Primary Outcome Measure

Exosomal Biomarkers Assessment [ Time Frame: up to 10 years after treatment completion ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Kansas Medical Center/ Cancer CenterKansas CityKansas66190
Leah Miller, MS
[email protected]
913-588-3670
Mindi TenNapel, PhD
[email protected]
913-945-9547
Andrew Hoover, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Kansas City, KS

By condition
Colorectal cancer
By specialty
OncologyGI oncology
By research site
University of Kansas Medical Center/ Cancer Center· Kansas City, KS

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