Facilitating Diagnostics and Prognostics of Parkinsonian Syndromes Using Neuroimaging

Conditions

• Multiple System Atrophy
• Parkinson Disease
• Progressive Supranuclear Palsy

Eligibility Criteria

Sex

ALL

Age

N/A - N/A

Healthy Volunteers

Accepted

Study Details

The goals of this study are: 1) to identify biomarkers using neuroimaging that are associated with progression rate using statistical methods, and 2) to identify biomarkers that are associated with the differential diagnosis of Parkinson's disease and atypical parkinsonism.

Key Dates

Start date

Mar 28, 2019

Status verified

Jan 2026

Primary completion

Dec 31, 2026

Completion

Dec 31, 2026

Study Design

Enrollment

90 participants (estimated)

Arms

• Arm: Aim 1: Develop a biomarker of PD disease progression rate
  For Aim 1, we will enroll PD subjects spanning a range of progression rates that have been tracked at UT Southwestern Medical Center. Multimodal neuroimaging will be acquired from each subject. We will evaluate imaging data and known data on clinical progression using statistical techniques to determine a biomarker that associates with progression rate.
• Arm: Aim 2: Develop a biomarker to distinguish between PD, PSP, MSA
  For Aim 2, we will recruit subjects with PD, MSA, and PSP. We will also recruit healthy age/sex-matched controls. All subjects will complete a series of clinical assessments at three different time points, roughly 6-8 months apart: * Levodopa Equivalent Daily Dose * Parkinson disease questionnaire * Schwab and England ADL Scale * MDS-UPDRS (PD and healthy controls only) * UMSARS (MSA subjects only) * PSPRS (PSP subjects only) Multimodal neuroimaging will be acquired from each subject. We will evaluate imaging data from the participants along with prospectively collected information on clinical progression using statistical techniques to determine a biomarker that associates with the differentiation of PD, MSA, and PSP.

Primary Outcome Measure

Imaging biomarker of progression rate [ Time Frame: Baseline ]

Central Contacts

• Padraig E O'Suilleabhain, MD
  214-648-2943
  [email protected]

Locations (1)

Find similar trials in Dallas, TX

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