Pencil Beam Scanning in Patients With Renal Tumors

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
Children's Hospital of Philadelphia
Study ID
NCT03810651
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Renal Tumor
  • Wilms Tumor

Eligibility Criteria

Sex
ALL
Age
0 Years - 30 Years
Healthy Volunteers
Not accepted

Interventions

  • Proton beam radiation using pencil beam scanning — OTHER
    Proton beam radiation using pencil beam scanning, characterized by Bragg peak dose deposition and high conformality of dose to target regions

Study Details

This is a pilot study to assess acute toxicity in patients receiving flank irradiation using proton therapy for renal tumors.

Key Dates

Start date
Dec 26, 2017
Status verified
Apr 2026
Primary completion
Oct 30, 2027
Completion
Oct 30, 2028

Study Design

Enrollment
28 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Other: Renal tumors
    Any patient with Wilms tumor or clear cell sarcoma of the kidney who would require radiation therapy as standard of care. Patients may receive an investigation drug for Wilms or CCSK given concurrently or within the first four weeks of the first fraction of proton therapy administration.

Primary Outcome Measure

Occurrence of any non-hematologic toxicity that occurs within 90 days following the start of proton therapy assessed with with NCI Common toxicity criteria (CTC Version 4.0) grades]. [ Time Frame: 90 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Children's Hospital of PhiladelphiaPhiladelphiaPennsylvania19104
Christine Hill-Kayser, MD
[email protected]
215-590-2810
Ratnakar Patti
[email protected]

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