OCT Angiography and NRAI in Dementia

Conditions

• Alzheimer Disease
• Dementia
• Mild Cognitive Impairment

Eligibility Criteria

Sex

ALL

Age

55 Years - N/A

Healthy Volunteers

Accepted

Interventions

• Optical Coherence Tomography Angiography (OCTA) Imaging — DEVICE
  Optical coherence tomography is a non-invasive imaging technology that provides cross-sectional images of tissues in micron-scale resolution. The angiography component of this device allows for evaluation of blood vessel and blood flow changes in the eye. The Solix device with AngioVue software will be used to detect these blood vessel and flow changes as well as protein deposits in the retinal layers.
• Noninvasive Retinal Amyloid Imaging (NRAI) — DEVICE
  The Spectralis will be used for NRAI. This system uses a special light source and optical filters to detect fluorescence of amyloid proteins in the eye.

Study Details

The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.

Key Dates

Start date

Sep 14, 2018

Status verified

Sep 2025

Primary completion

Dec 31, 2026

Completion

Dec 31, 2027

Study Design

Enrollment

20 participants (estimated)

Arms

• Arm: Early Dementia
  This group will consist of adults with suspected dementia/Alzheimer's Disease. OCTA and NRAI data will be gathered in one study visit.
• Arm: Dementia-Free Controls
  This group will consist of adults without suspected dementia/Alzheimer's Disease. OCTA and NRAI data will be gathered in one study visit.

Primary Outcome Measure

Retinal amyloid protein detection [ Time Frame: 1 day ]

Central Contacts

• Denzil Romfh, OD
  503-494-4351
  [email protected]
• Humberto Martinez, COT
  503-494-7712
  [email protected]

Locations (1)

Find similar trials in Portland, OR

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