Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: a Dimensional Approach

Conditions

• Neuropsychiatric Syndromes

Eligibility Criteria

Sex

ALL

Age

18 Years - 80 Years

Healthy Volunteers

Accepted

Interventions

• PET with radiotracer [11C]PBR-28 ( or [11C]ER176) — DRUG
  \[11C\]PBR-28 or \[11C\]ER176 will be injected into subjects' veins during PET scanning.
• Affective challenge — OTHER
  Affective challenge is the induction of, for example, mood or affective pain.

Study Details

The purpose of this research is to determine whether there is more extensive inflammation in the brain of people with clinical evidence of neuropsychiatric syndromes, such as mood disorder, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation in the brain will identified by using Positron Emission Tomography (PET) with the radiotracer \[11C\]PBR-28 or \[11C\]ER176.

Key Dates

Start date

May 1, 2017

Status verified

Mar 2025

Primary completion

Aug 31, 2028

Completion

Aug 31, 2028

Study Design

Enrollment

200 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: PET with radiotracer [11C]PBR-28 or [11C]ER176
  PET with radiotracer \[11C\]PBR-28 or \[11C\]ER176 will be performed. \[11C\]PBR-28 or \[11C\]ER176 will be injected into subjects' veins during PET scanning.
• Experimental: PET with radiotracer [11C]PBR-28 or [11C]ER176 and affective challenge
  PET with radiotracer \[11C\]PBR-28 or \[11C\]ER176 will be performed. \[11C\]PBR-28 or \[11C\]ER176 will be injected into subjects' veins during PET scanning. Affective challenge (e.g. induction of mood, affective pain) will be presented to the patient during the PET scanning period.

Primary Outcome Measure

Level of TSPO expression as quantified by PET imaging to detect binding of the TSPO radiotracer [11C]PBR-28 [ Time Frame: obtained during PET scanning (between 1:30 PM and 3 PM) at study baseline within a few days of study enrollment ]

Central Contacts

• Alan Prossin, MBBS
  713-486-2836
  [email protected]

Locations (1)

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