Preoperative Fractionated Radiation Therapy Versus Stereotactic Body Radiation Therapy for Resectable or Borderline Resectable, or Locally Advanced Type A Pancreatic Adenocarcinoma

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
Medical College of Wisconsin
Study ID
NCT03704662
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Stereotactic Body Radiation Therapy — RADIATION
    Undergo SBRT
  • Preoperative Fractionated Radiation Therapy and Chemotherapy — RADIATION
    Conventional concurrent chemotherapy and radiation therapy.

Study Details

Patients are randomized into two arms. Arm A patients will receive Stereotactic Body Radiation Therapy (SBRT) and Arm B patients with receive conventional concurrent chemotherapy and radiation therapy.

Key Dates

Start date
Oct 22, 2018
Status verified
Oct 2025
Primary completion
Jun 1, 2026
Completion
Jun 1, 2031

Study Design

Enrollment
102 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Other: Stereotactic Body Radiation Therapy
    Patients undergo Stereotactic Body Radiation Therapy (25 to 35 Gy over five fractions)
  • Other: Preoperative Fractionated Radiation Therapy and Chemotherapy
    Concurrent chemotherapy with radiation treatment (50.4 Gy over 28 fractions).

Primary Outcome Measure

The number of subjects who present with node-positive disease following surgical resection. [ Time Frame: 8 weeks postradiation ]

Central Contacts

  • Medical College of Wisconsin Cancer Center Clinical Trials Office
    414-805-8900
    [email protected]

Locations (1)

FacilityCityStateZIPSite coordinators
Froedtert Hospital & Medical College of WisconsinMilwaukeeWisconsin53226
Medical College of Wisconsin Cancer Center Clinical Trials Office
[email protected]
414-805-8900

Find similar trials in Milwaukee, WI

By condition
Pancreatic cancer
By specialty
OncologyGI oncology
By research site
Froedtert Hospital & Medical College of Wisconsin· Milwaukee, WI

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