Autologous Ovarian Tissue Transplantation

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT03496636
Status
Recruiting
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Conditions

  • Female Infertility

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Ovarian tissue transplant — PROCEDURE
    Pieces of previously frozen ovarian cortex will be put in the abdomen laparoscopically, or with mini laparotomy

Study Details

Chemotherapy and radiation for cancer and other conditions can cause infertility. Several centers around the world are cryopreserving ovarian tissue from these patients though an experimental protocol, including the Fertility Preservation Program in Pittsburgh (protocol PRO08050491). The objective of this study is to study the efficacy and safety of autologous tissue transplantation in patients diagnosed with primary ovarian insufficiency after chemotherapy and/or radiation treatments.

Key Dates

Start date
Mar 1, 2021
Status verified
Aug 2025
Primary completion
Sep 1, 2026
Completion
Sep 1, 2027

Study Design

Enrollment
5 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Ovarian tissue transplant
    Transplantation of ovarian tissue into the abdomen. Only for patients who have previously frozen ovarian tissue

Primary Outcome Measure

Change in reproductive hormone levels after ovarian tissue transplant [ Time Frame: 1,3,6,9,12 and 24 months post-transplantation ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Magee-Womens HospitalPittsburghPennsylvania15213
Jennifer Anglin
[email protected]
412-641-7475

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By research site
Magee-Womens Hospital· Pittsburgh, PA

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