PET Imaging CCR2 in Lung Inflammation

Part of paid clinical trials in St Louis, Missouri.

Sponsor
Washington University School of Medicine
Study ID
NCT03492762
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Lung Inflammation

Eligibility Criteria

Sex
ALL
Age
21 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Cu-DOTA-ECL1i — DRUG
    Radiolabeled probe called Cu-DOTA-ECL1i that recognizes CCR2 and propose to image CCR2 in the lung to ultimately guide diagnosis and therapy.

Study Details

The primary objective of this study is to assess the lung distribution of the Positron Emission Tomography (PET) imaging radiotracer Cu-DOTA-ECL1i, which binds to the specific population inflammatory cells, in patients with fibrotic lung diseases. This objective includes sub-studies to assess radiotracer distribution in the lung, the reproducibility of PET scans and the relationship of the scan to distribution of inflammatory cells in human lung tissue. The overall goal is to assess the potential of the radiotracer to track inflammatory cells in lung diseases.

Key Dates

Start date
Feb 27, 2018
Status verified
Apr 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
110 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC

Arms

  • Experimental: Healthy Volunteer Group
    The healthy volunteer group will receive the same interventions as the ILD documented diagnosed volunteer group
  • Experimental: ILD Documented Diagnosed Volunteer Group
    The ILD documented diagnosed volunteer group will receive the same interventions as the healthy volunteer group

Primary Outcome Measure

Change of uptake of Cu-DOTA-ECL1i to lung fibrosis [ Time Frame: Through study completion ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Washington University School of MedicineSt LouisMissouri63110
Steven Brody, MD
[email protected]
314-362-8969

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By research site
Washington University School of Medicine· St Louis, MO

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