Incidence of HANA Conditions in HIV-infected Individuals

Sponsor
Chinese University of Hong Kong
Study ID
NCT03483584
Status
Completed

Conditions

  • HIV
  • Liver Fibroses
  • Metabolic Syndrome
  • Osteopenia
  • Osteoporosis
  • Renal Impairment
  • Vitamin D Deficiency

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

With the availability of effective anti-retroviral therapy, HIV-infected individuals are expected not to die of AIDS and have longer life expectancy. But at the same time, HIV-associated non-AIDS (HANA) conditions are becoming more important in their clinical management. It is currently uncertain whether patients started on different anti-retroviral regimens will have different incidence of HANA conditions. This study aims to evaluate the incidence of various HANA conditions in a cohort of newly diagnosed HIV-infected individuals in Hong Kong initiating anti-retroviral treatment. The incidence of various HANA conditions will be evaluated for those receiving INSTI versus other non-INSTI-based regimens. The HANA conditions evaluated will include 1. Hypertension 2. Diabetes and insulin resistance 3. Dyslipidemia 4. Lipodystrophy 5. Metabolic syndrome 6. Osteopenia and osteoporosis 7. Vitamin D deficiency 8. Renal impairment and kidney tubular dysfunction and 9. Liver fibrosis. Patients will be assessed prior to initiation of anti-retroviral therapy, and 48 weeks and 96 weeks after initiation of treatment. The incidence of development of each HANA condition will be determined and compared between those initiated different anti-retroviral regimens.

Key Dates

Start date
Apr 6, 2018
Status verified
Nov 2025
Primary completion
Mar 31, 2024
Completion
Sep 30, 2024

Study Design

Enrollment
215 participants (actual)

Arms

  • Arm: INSTI
    INSTI-containing ART regimens
  • Arm: non-INSTI
    non-INSTI-containing ART regimens

Primary Outcome Measure

Prevalences of HIV-associated Non-AIDS Conditions (HANA) [ Time Frame: Baseline ]

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