Indwelling Pleural Catheters With or Without Doxycycline in Treating Patients With Malignant Pleural Effusions

Conditions

• Pleural Neoplasm

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Doxycycline — DRUG
  Receive via IPC
• Indwelling Catheter — DEVICE
  Receive IPC
• Quality-of-Life Assessment — PROCEDURE
  Ancillary studies
• Questionnaire Administration — OTHER
  Ancillary studies
• Survey Administration — OTHER
  Ancillary studies

Study Details

This study is designed to obtain preliminary data comparing indwelling pleural catheters (IPCs) versus IPCs plus doxycycline for pleurodesis as treatments for malignant pleural effusion (MPE). Indwelling pleural catheters (IPCs) are commonly used to treat pleural effusions (build-up of fluid in the lungs). Doxycycline is an antibiotic that is also used to treat pleural effusions. The goal of this clinical research study is to learn if adding doxycycline to the use of an IPC can lead to shorter treatment times with IPCs.

Key Dates

Start date

Mar 8, 2018

Status verified

Mar 2026

Primary completion

Dec 1, 2028

Completion

Dec 1, 2028

Study Design

Enrollment

208 participants (estimated)

Arms

• Arm: Group 2 (IPC alone)
  Patients undergo IPC placement.
• Arm: Group I (IPC, doxycycline)
  Patients undergo IPC placement and receive doxycycline via IPC 5 days later.

Primary Outcome Measure

Time to pleural catheter removal [ Time Frame: Up to 1 year ]

Central Contacts

• David Ost
  713-792-6238
  [email protected]

Locations (1)

Find similar trials in Houston, TX

Related Studies

• Phase II Trial of Lung Chemoemobolization
  PHASE2 · Recruiting · City of Hope Medical Center · Duarte, California