Glucose Absorption and Gut Hormone Secretion After Gastric Bypass

Sponsor
Hvidovre University Hospital
Study ID
NCT03426956
Status
Unknown

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Glucose — DIETARY_SUPPLEMENT
    Ingestion of glucose (50 g) dissolved in 200 ml water.
  • Glucose + Canagliflozin — DIETARY_SUPPLEMENT
    Ingestion of glucose (50 g) dissolved in 200 ml water combined with the SGLT-1/SGLT-2 inhibitor canagliflozin.

Study Details

To investigate the impact of canagliflozin on secretion of gut hormones, in particular glucagon-like peptide 1 (GLP-1) in gastric bypass operated patients.

Key Dates

Start date
Feb 8, 2018
Status verified
Feb 2018
Primary completion
May 1, 2019
Completion
May 1, 2019

Study Design

Enrollment
10 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Glucose
  • Experimental: Glucose + Canagliflozin

Primary Outcome Measure

Difference in GLP-1 secretion (evaluated by iAUC). [ Time Frame: 0-240 min following glucose ingestion ]

Central Contacts

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