Electrographic Seizure Management and Neurobehavioral Outcomes in Critically Ill Children

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
Children's Hospital of Philadelphia
Study ID
NCT03419260
Status
Recruiting
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Conditions

  • Seizures

Eligibility Criteria

Sex
ALL
Age
1 Month - 18 Years
Healthy Volunteers
Not accepted

Interventions

  • Clinically indicated EEG monitoring. — OTHER
    Children enrolled in the study will be undergoing clinically indicated EEG monitoring. Some children will undergo clinically indicated electrographic seizure management.

Study Details

Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of the efficacy or safety of specific anti-seizure medications or overall management strategies. This is a single-center prospective observational study. The investigators aim to: (1) track critically ill patients undergoing clinically indicated EEG monitoring and seizure management to identify risk factors for electrographic seizures, (2) create prediction models guiding EEG monitoring resources to the patients at highest risk for seizures, and (3) evaluate our current management strategy in terms of safety.

Key Dates

Start date
Mar 13, 2017
Status verified
Feb 2025
Primary completion
Jan 1, 2027
Completion
Jan 1, 2027

Study Design

Enrollment
2,500 participants (estimated)

Arms

  • Arm: Cohort
    Critically ill child undergoing clinically indicated EEG monitoring and electrographic seizure management.

Primary Outcome Measure

Electrographic Seizure Occurrence [ Time Frame: 3 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Children's Hospital of PhiladelphiaPhiladelphiaPennsylvania19104
Nichoals S Abend, MD
215-590-1719

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Children's Hospital of Philadelphia· Philadelphia, PA

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