Defining the Skin and Blood Biomarkers of Ichthyosis

Part of paid clinical trials in Chicago, Illinois.

Sponsor
Northwestern University
Study ID
NCT03417856
Status
Enrolling By Invitation

Conditions

  • Ichthyosis
  • Netherton Syndrome

Eligibility Criteria

Sex
ALL
Age
1 Year - 60 Years
Healthy Volunteers
Accepted

Study Details

Ichthyosis is a group of genetic skin disorders that present with dry, thickened, scaly, or flaky skin. As of today, there is no cure or treatment. Doctors can only treat the dry skin with different types of emollients to soften the scale. A deeper understanding of this disease is required to develop better treatments. There are different types of cells and cell-produced signals (biomarkers) that are being studied in order to help find these new treatments. Looking at biomarkers has been successful in helping us to understand other skin disorders better. The purpose of this study is to determine which blood and skin biomarkers characterize ichthyosis. Hypothesis: We predict that the biomarkers correlating with disease activity in Netherton syndrome will be different than the biomarkers found to correlate with the lamellar and other ichthyosis phenotype.

Key Dates

Start date
Jan 31, 2018
Status verified
Apr 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Control
    Healthy subjects with no history of ichthyosis from 1 year to 60 years of age.
  • Arm: Ichthyosis
    Subjects with a diagnosis of Netherton syndrome or ichthyosis from 1 year to 60 years of age.

Primary Outcome Measure

Cellular infiltrates [ Time Frame: One year ]

Locations (4)

FacilityCityStateZIPSite coordinators
Ann & Robert H. Lurie Children's Hospital of ChicagoChicagoIllinois60611-
Northbrook Lurie Children's Outpatient ClinicChicagoIllinois60611-
Northwestern UniversityChicagoIllinois60611-
Icahn School of Medicine at Mount SinaiNew YorkNew York10029-

Find similar trials in Chicago, IL

By research site
Ann & Robert H. Lurie Children's Hospital of Chicago· Chicago, ILNorthbrook Lurie Children's Outpatient Clinic· Chicago, ILNorthwestern University· Chicago, ILIcahn School of Medicine at Mount Sinai· New York, NY

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