Biology of Juvenile Myoclonic Epilepsy

Conditions

• Juvenile Myoclonic Epilepsy

Eligibility Criteria

Sex

ALL

Age

10 Years - 40 Years

Healthy Volunteers

Not accepted

Interventions

• Blood draw — OTHER
  Participation includes one visit for one blood draw per recruited patient. 10-20ml peripheral venous blood will be taken from the antecubital fossa. The DNA from the blood sample will then be extracted and resequenced for analysis.
• Existing samples — OTHER
  Control DNA samples will be used that have been previously acquired in other studies.

Study Details

The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.

Key Dates

Start date

Jul 13, 2017

Status verified

Aug 2025

Primary completion

Jun 30, 2026

Completion

Dec 31, 2026

Study Design

Enrollment

1,000 participants (estimated)

Arms

• Arm: Patients diagnosed with JME
  People who meet the eligibility requirements and have been diagnosed with juvenile myoclonic epilepsy.
• Arm: Controls
  People without a lifetime history of seizures.

Primary Outcome Measure

Genomewide DNA association study [ Time Frame: Day 1 ]

Central Contacts

• Deb K Pal, MD PhD
  +442078480608
  [email protected]

Locations (3)

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