Simplified Isoniazid Preventive Therapy Strategy to Reduce TB Burden

Sponsor
University of California, San Francisco
Study ID
NCT03315962
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • SPIRIT Intervention — BEHAVIORAL
    The intervention will include implementing a teaching collaborative among group of DHOs and TB Supervisors, enabling text messaging between DHOs and front line providers, and establishing a report collaborative where DHOs will receive feedback on the performance of their district in administering IPT compared to other districts.

Study Details

The overall objective of this study is to determine if a multi-component implementation intervention (SPIRIT) and additional leadership and management training that targets District Health Officers (DHOs) can increase IPT initiation among HIV-infected persons, as compared to country standard practices, in a cluster randomized trial in Uganda.

Key Dates

Start date
Nov 15, 2017
Status verified
Jun 2025
Primary completion
Nov 30, 2023
Completion
Nov 30, 2023

Study Design

Enrollment
163 participants (actual)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Experimental: Aim 1: DHO Intervention Arm
    A selection of DHO or TB district supervisors that are randomized to the multicomponent SPIRIT intervention.
  • No Intervention: Aim 1: DHO Control Arm
    A selection of DHO or TB district supervisors that are randomized to the country standard of care, but not to receive the study intervention.

Primary Outcome Measure

IPT Initiation Rate [ Time Frame: 2 years ]

Related Studies