Changes in Esophageal Distensibility With Proton Pump Inhibitors in Patients With Esophageal Eosinophilia: A Pilot Study

Part of paid clinical trials in Indianapolis, Indiana.

Sponsor
Indiana University
Study ID
NCT03312686
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • endoflip — DIAGNOSTIC_TEST
    Resolution of esophageal eosinophilia by a 2-month course of high dose PPI in patients will lead to improvement in esophageal distensibility, and thus should produce improvement in dysphagia symptoms.

Study Details

This pilot study will explore whether treatment of eosinophilic inflammation in the esophagus is associated with an improved distensibility of the esophagus. Furthermore, previous studies of the esophagus using EndoFlip only measured distensibility of the distal esophagus, specifically the distal esophagus and esophagogastric junction. Eosinophilia in EoE has been demonstrated to affect both upper, middle and lower esophagus. The aim is to measure distensibility both proximal and distal, before and after treatment.

Key Dates

Start date
Nov 30, 2016
Status verified
Nov 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
10 participants (estimated)

Arms

  • Arm: Eosinophilic Esophagitis patients
    PPI treatment

Primary Outcome Measure

Change in Esophageal Distensibility before and after treatment [ Time Frame: 2 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Indiana UniversityIndianapolisIndiana46202-
Indiana University Health University HospitalIndianapolisIndiana46202
Maureen Schilling
[email protected]
Akiro Saito, MD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Indianapolis, IN

By research site
Indiana University· Indianapolis, INIndiana University Health University Hospital· Indianapolis, IN

Related Studies