Cerebellar Stimulation and Cognitive Control

Part of paid clinical trials in Iowa City, Iowa.

Sponsor
Krystal Parker, PhD
Study ID
NCT03217110
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 90 Years
Healthy Volunteers
Accepted

Interventions

  • Repetitive Transcranial Magnetic Stimulation (rTMS) — DEVICE
    Subjects with neuropsychiatric diagnoses and matched-controls will be receive theta frequency stimulation of the cerebellum. We will target the cerebellar vermis.
  • Sham Repetitive Transcranial Magnetic Stimulation (rTMS) — DEVICE
    Subjects with neuropsychiatric diagnoses and matched-controls will be receive sham stimulation of the cerebellum. We will target the cerebellar vermis.

Study Details

The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

Key Dates

Start date
Nov 30, 2017
Status verified
Mar 2026
Primary completion
Dec 1, 2028
Completion
Dec 1, 2028

Study Design

Enrollment
200 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: patient active rTMS
    Subjects will receive 5 days of 2x daily rTMS targeted over the cerebellum.
  • Sham Comparator: patient sham rTMS
    Subjects will receive 5 days of 2x daily sham stimulation of the cerebellum.
  • Active Comparator: Control active rTMS
  • Sham Comparator: Control sham rTMS

Primary Outcome Measure

Change in disease-specific symptom rating scale, one scale identified for each group (MADRS for bipolar group; PANSS for schizophrenia group; UPDRS in Parkinson's patient group). [ Time Frame: During the 1 week of treatment, with follow up 1 week, 3 weeks, and 2 months post-stimulation. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of IowaIowa CityIowa52245
Krystal L Parker, Ph.D
[email protected]
319-353-3554

Find similar trials in Iowa City, IA

By condition
Autism spectrum disorderBipolar disorderDepressionParkinson's diseaseSchizophrenia
By specialty
PediatricsPsychiatryMental healthBehavioral healthNeurologyBrain disorders
By research site
University of Iowa· Iowa City, IA

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